From Highway 101 Heading North:

Take HIGHWAY 101 north towards the I-380 WEST RAMP in San Bruno. Merge onto HIGHWAY 380 heading west. Take the HIGHWAY 280 NORTH RAMP towards SAN FRANCISCO and merge onto HIGHWAY 280. Then take the JUNIPERO SERRA BLVD/HIGHWAY 1 SOUTH RAMP heading towards PACIFICA/MISSION STREET. Merge onto HIGHWAY 1 SOUTH RAMP and take the highway to the first exit, which is CLARINADA AVENUE. Turn left onto CLARINADA AVE. Then turn right onto ST. FRANCIS BLVD, and then turn right onto SOUTHGATE AVENUE. St. Francis Ophthalmology Group is at 1440 SOUTHGATE AVENUE.

From Highway 101 Heading South:

Take HIGHWAY 101 south to the HIGHWAY 280 SOUTH RAMP and merge onto HIGHWAY 280. Take HIGHWAY 280 south to the EASTMOOR AVE/MISSION ST exit. Then turn left onto SULLIVAN AVENUE. Then turn right onto SOUTHGATE AVENUE. St. Francis Ophthalmology Group is at 1440 SOUTHGATE AVENUE.

From Highway 280 Heading North:

Take HIGHWAY 280 to the JUNIPERO SERRA BLVD/HIGHWAY 1 SOUTH RAMP heading towards PACIFICA/MISSION STREET. Merge onto HIGHWAY 1 SOUTH RAMP and take the highway to the first exit, which is CLARINADA AVENUE. Turn left onto CLARINADA AVE. Then turn right onto ST. FRANCIS BLVD, and then turn right onto SOUTHGATE AVENUE. St. Francis Ophthalmology Group is at 1440 SOUTHGATE AVENUE.

From Highway 280 Heading South:

Take HIGHWAY 280 south to the EASTMOOR AVE/MISSION ST. exit. Take exit and then turn left onto SULLIVAN AVENUE. Then turn right onto SOUTHGATE AVENUE. St. Francis Ophthalmology Group is at 1440 SOUTHGATE AVENUE.

From South San Francisco:

Take GRAND AVE in South San Francisco west towards CHESTNUT AVENUE. Turn right onto EL CAMINO REAL heading north. Then turn left onto Hickey BLVD. Then turn SLIGHT RIGHT onto JUNIPERO SERRA BLVD. Turn LEFT onto SOUTHGATE AVE. St. Francis Ophthalmology Group is at 1440 SOUTHGATE AVENUE.

From Brisbane and Bayshore Park Areas:

Take BAYSHORE BLVD west towards Daly City. Turn left onto GUADALUPE CANYON PKWY. GUADALUPE CANYON PKWY will then become EAST MARKET ST. Then EAST MARKET ST will become SAN PEDRO RD. Take SAN PEDRO RD. to SULLIVAN AVE and turn left. Now turn right onto SOUTHGATE AVE. St. Francis Ophthalmology Group is at 1440 SOUTHGATE AVENUE.

From Pacifica and Half Moon Bay Areas:

Take Highway 1 north to the SERRAMONTE BOULEVARD exit. Turn right onto SERRAMONTE BLVD. Turn right onto ST FRANCIS BLVD. Turn right onto SOUTHGATE AVENUE. St. Francis Ophthalmology Group is at 1440 SOUTHGATE AVENUE.